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Lab Retreat at Silver Bench

May 27, 2019April 1, 2020

This is a long-delayed summer… the water still cold; the sky is still cloudy. But we have a lot of fun. Farewell Sindy… Keep us posted 🙂

S.Zhang Lab Follow

Explorers in the wilderness of cancer biology

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Feng Zhang @zhangf ·

12 Jan

Congratulations to @rumya_r @mircoscopy @DStrebinger @blake_lash @cyrusbiotech and colleagues on an exciting study combining AI and protein engineering to minimize the immunogenicity of Cas9 and Cas12a nucleases. These approaches have the potential to improve the safety and…

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Metastasis Research Society @metastasisrs ·

31 Dec

7/Epigenetic states define disseminated tumor cell (DTC) fate. In this study, the authors find that hypomethylated DTCs respond to WNT ligands, extravasate and undergo dormancy, while methylated DTCs proliferate intravascularly.

@moviqu @HellmutAugustin

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Patrick Hsu @pdhsu ·

14 Nov

Today we report Evo, a generalist foundation model for biology, on the cover of @ScienceMagazine. Trained on billions of DNA nucleotides, Evo was designed to capture two key aspects of biology: the multi-modality of the central dogma and the multi-scale nature of evolution.

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Matthia Karreman @ma_karreman ·

7 Oct

How do T cells reach melanoma brain tumors?

Using in vivo microscopy, we discovered a new route for T cells to enter the brain via distinct peri-tumoral venous vessels.

Our newest paper is now online @ImmunityCP.
https://authors.elsevier.com/sd/article/S1074-7613(24)00447-3

A 🧵👇

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