Publications

Most Recent Publications (selected)

  • Palakurthi B, Fross S, Guldner IH, Aleksandrovic E, Liu X, Martino AK, Wang Q, Neff RA, Golomb SM, Lewis C, Peng Y, Howe EN, Zhang S, 2023. Targeting CXCL16 and STAT1 Augments Immune Checkpoint Blockade Therapy in Triple-Negative Breast Cancer. Nat. Commun. 2023 Apr 13;14(1):2109. doi: 10.1038/s41467-023-37727-y. [Full-text]
  • Bahcecioglu G, Yue X, Howe E, Guldner IH, Stack MS, Nakshatri H, Zhang S, Zorlutuna P. Aged Breast Extracellular Matrix Drives Mammary Epithelial Cells to an Invasive and Cancer-Like Phenotype. Adv Sci (Weinh). 2021 Nov;8(22):e2100128. doi: 10.1002/advs.202100128. Epub 2021 Oct 7. PubMed PMID: 34617419; PubMed Central PMCID: PMC8596116. [Full-text]
  • Guldner IH, Golomb SM, Wang Q, Wang E, and Zhang S. Isolation of mouse brain-infiltrating leukocytes for single cell profiling of epitopes and transcriptomes. STAR Protoc. 2021. 2, 100537. [Full-text]
  • Xu C, Sun S, Johnson T, Qi R, Zhang S, Zhang J, and Yang K (2021). The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity. Cell Rep. 35, 109235. [Full-text]
  • Zhang Y, Guldner IH, Nichols EL, Benirschke D, Smith CJ, Zhang S, Howard SS. High-speed, long-term, 4D in vivo lifetime imaging in intact and injured zebrafish and mouse brains by instant FLIM. Optica, Vol. 8, Issue 6, pp. 885-897 (2021) [Full-text]
  • Golomb SM, Guldner IH, Zhao A, Wang Q, Palakurthi B, Aleksandrovic EA, Lopez J, Lee WS, Yang K, Zhang S. Multi-modal single cell analysis reveals brain immune landscape plasticity during aging and gut microbiota dysbiosis. Cell Reports 2020 Dec 1; 33(9): 108438 https://doi.org/10.1101/2020.07.15.205377 [Full text]
  • Guldner IH, Wang Q, Yang L, Golomb SM, Zhao A, Lopez JA, Brunory A, Howe EN, Zhang Y, Palakurthi B, Barron M, Gao H, Xuei X, Liu Y, Li J, Chen DZ, Landreth GE, Zhang S. CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10. Cell 2020 Nov 25;183(5):1234-1248.e25. doi: 10.1016/j.cell.2020.09.064. [Full text] [PDF]
  • Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M, Chen J. Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity. JCI Insight. 2020 Aug 6;5(15):e139237. doi: 10.1172/jci.insight.139237. PMID: 32759497; PMCID: PMC7455083.
  • Howe EN, Burnette MD, Justice ME, Clancy JW, Guldner IH, Schnepp PM, Hendrick V, Aryal UK, Specht AT, Li J, D’Souza-Schorey C, Zartman JZ, and Zhang S. Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth. Nat Commun. 2020 Jun 15;11(1):3017. doi: 10.1038/s41467-020-16832-2. BioRxiv 666750. [Full text]
  • Wang Q, Guldner IH, Golomb SM, Sun L, Harris J, Lu X, and Zhang S. Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor resistant HER2-positive breast cancer. Nat Commun. 2019 Aug 23;10(1):3817. doi: 10.1038/s41467-019-11729-1. BioRxiv 671198 Read news here. [Full text]
  • Rodriguez KX, Howe EN, Bacher EP, Burnette M, Meloche JL, Meisel J, Schnepp P, Tan X, Chang M, Zartman JZ*, Zhang S*, Ashfeld BL*, 2019. Combined Scaffold Evaluation and Systems-Level Transcriptome-Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes. ChemMedChem. https://doi.org/10.1002/cmdc.201900266 [Epub ahead of print] [Full text] *: corresponding authors.
  • Ni Y, Schmidt KR, Werner BA, Koenig JK, Guldner IH, Schnepp PM, Tan X, Jiang L, Host M, Sun L, Howe EN, Wu J, Littlepage LE, Nakshatri H, Zhang S. Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer. Nat Commun. 2019 Jun 28;10(1):2860. doi: 10.1038/s41467-019-10743-7. [Full text]
  • Zhang Y, Nichols EL, Zellmer AM, Guldner IH, Kankel C, Zhang S, Howard SS, Smith CJ. Generating intravital super-resolution movies with conventional microscopy reveals actin dynamics that construct pioneer axons. Development. 2019; 146(5). [Full text]
  • Yue X, Nguyen TD, Zellmer V, Zhang S, Zorlutuna P. Stromal cell-laden 3D hydrogel microwell arrays as tumor microenvironment model for studying stiffness dependent stromal cell-cancer interactions. Biomaterials. 2018; 170:37-48. [Full text]
  • Barron M, Zhang S, Li J. A sparse differential clustering algorithm for tracing cell type changes via single-cell RNA-sequencing data.Nucleic Acids Res. 2018;46:e14. [Full text]
  • Yue X, Nguyen TD, Zellmer V, Zhang S, Zorlutuna P. Stromal cell-laden 3D hydrogel microwell arrays as tumor microenvironment model for studying stiffness dependent stromal cell-cancer interactions. Biomaterials. 2018;170:37–48. [Full text]
  • ZellmerVR, Schnepp PM, Fracci SL, Tan X, Howe EN, Zhang S. Tumor-induced stromal STAT1 accelerates breast cancer via deregulating tissue homeostasis. Mol Cancer Res. 2017;15:585–97. [Full text]
  • Schnepp PM, Lee DD, Guldner IH, O’Tighearnaigh TK, Howe EN, Palakurthi B … Zhang S. GAD1 upregulation programs aggressive features of cancer cell metabolism in the brain metastatic microenvironment. Cancer Res. 2017;77:2844–56. [Full text]
  • Guldner IH, Yang L, Cowdrick KR, Wang Q, Barrios WVA, Zellmer VR, .. Zhang S. An integrative platform for three-dimensional quantitative analysis of spatially heterogeneous metastasis landscapes. Sci Rep. 2016;6:24201. [Full text]
  • Zhang L*, Zhang S*, Yao J, Lowery FJ, Zhang Q, Huang W-C, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015;527:100–4. *: co-first authors. [Full text]
  • Zhang S, Huang W-C, Zhang L, Zhang C, Lowery FJ, Ding Z, et al. Src family kinases as novel therapeutic targets to treat breast cancer brain metastases. Cancer Res. 2013;73:5764–74. [Full text]
  • Zhang S, Huang W-C, Li P, Guo H, Poh S-B, Brady SW, et al. Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat Med. 2011;17:461-U101. [Full text]
  • Zhang S, Yu D. PI(3)king apart PTEN’s role in cancer. Clin Cancer Res 2010;16:4325–30. [Full text]

Check out the complete “List of Published Work” here.